Nematodes and weevils of banana with Panama disease (Fusarium oxysporum f. sp. cubense) globally affect food security, causing yearly crop losses for many billion € in Canary Islands, Caribbean and Africa. These threats concomitantly affect crops in tropical and sub-tropical systems. In regions such as Sub Saharan Africa (SSA) millions of farmers rely on cooking banana, plantain and ensete both as primary staple food crop and for their income. Pesticides no longer represent a sustainable option for control, and many active compounds have been progressively withdrawn from use in the EU or are highly restricted, due to harmful effects on the environment and toxic residues. In SSA, where phytosanitary policies and regulations are often less effective, such pesticides are still being used, posing a significant threat to farmers and consumers. In the absence of long term strategies or suitable control methods, and under the influence of changing climates in tropical and subtropical regions, the banana crops are becoming ever more exposed to pathogens and pests due to higher multiplication rates and prevalence, induced by changing temperatures and rainfall patterns. The principal outcome of this project will be to achieve sustainable intensification of Musa spp. and ensete crops, through identification, development and implementation of integrated pest management strategies (IPM) based on beneficial microorganisms. MUSA proposes, in a holistic view, IPM methods based on microbial consortia and banana germplasm, studying the plant reactions (phenotypic and molecular) to different biotic stresses. This will be achieved by screening, testing and evaluating in the field selected banana lines, in an attempt to identify (via transcriptomic analyses) the principal genes involved in a resistant/succumbent response, and the interaction with beneficial microorganisms. The latter include endophytes and biocontrol agents integrated with plant germplasm to develop information-based IPM strategies through field trials. Communication and dissemination activities will be implemented, through the use of various tools, including the organization of farming schools, seminars and the use of communication and information technologies targeting final users and stakeholders.