Gian Paolo Accotto

DIRECTOR

Presently the main interest is in understanding the response of plants to viral infections. The model plant is tomato, and the viruses are TSWV and TYLCSV. Modifications in plant gene expression is analysed using microarrays, qRT-PCR, siRNA-seq, as well as bioinformatics.
The impact of symbiotic interaction between tomato and mycorrhizal fungi on the establishment of virus infection is also investigated, with the aim to define if mycorrhization plays a beneficial role in this plant/pathogen interaction or not. This is analysed using transcriptomics as well as by studying phytohormone regulation.
Recently, recombinant molecules between the two Begomovirus species TYLCSV and TYLCV were characterized from tomato samples collected in Sicily, highlighting the plasticity of geminivirus genomes.
Another field of interest is virus resistance, either by genetic modification of the plant genome (transgenic plants), or using naturally occurring genes (classical breeding), targetting TYLCSV and TSWV. An antiviral strategy against geminiviruses was patented.

Projects

Patents

Articles and book chapters since 2008

  • 2018 - First Report of Tomato leaf curl New Delhi virus Associated with Severe Mosaic of Pumpkin in Italy - Parrella G., Troiano E., Formisano G., Accotto G.P., Giorgini M. - Plant Disease , 102: 459
  • 2018 - Impact of high phosphorous and sodium on productivity and stress tolerance of Arundo donax plants - Cocozza C., Brilli F., Miozzi L., Pignattelli S., Rotunno S., Brunetti C., Giordano C., Pollastri S., Centritto M., Accotto G.P., Tognetti R., Loreto F. - Holzforschung ,
  • 2018 - Virus-mediated export of chromosomal DNA in plants - Catoni M., Noris E., Vaira A.M., Jonesman T., Matic S., Soleimani R., Behjatnia S.A.A., Vinals N., Paszkowski J., Accotto G.P. - Nature communications , volume 9
  • 2018 - Viruses and phytoparasitic nematodes of Cicer arietinum L.: biotechnological approaches in interaction studies and for sustainable control - Leonetti, P., Accotto, G.P., Hanafy, M. S., Pantaleo V. - Frontiers In Plant Science , volume 9
  • 2017 - First report of chickpea chlorotic dwarf virus in watermelon (Citrullus lanatus) in Tunisia - Zaagueri T., Mnari-Hattab M., Zammouri S., Hajlaoui M.R., Accotto G.P., Vaira A.M. - Plant Disease , 101: 392
  • 2017 - Deep Sequencing Data and Infectivity Assays Indicate that Chickpea Chlorotic Dwarf Virus is the Etiological Agent of the “Hard Fruit Syndrome” of Watermelon - Zaagueri T., Miozzi L., Mnari-Hattab M., Noris E., Accotto G.P., Vaira A.M. - Viruses , volume 9
  • 2017 - Pyramiding Ty-1/Ty-3 and Ty-2 in tomato hybrids dramatically inhibits symptom expression and accumulation of tomato yellow leaf curl disease inducing viruses - Tabein S., Behjatnia S.A.A., Laviano L., Pecchioni N., Accotto G.P., Noris E., Miozzi L. - Archiv Für Phytopathologie Und Pflanzenschutz , 50: 213-227
  • 2017 - Seed transmission of Beet curly top virus and Beet curly top Iran virus in a local cultivar of petunia in Iran - Anabestani A., Behjatnia S.A.A., Izadpanah K., Tabein S., Accotto G.P. - Viruses, volume 9
  • 2017 - In silico prediction of miRNAs targeting ToLCVand their regulation in susceptible and resistant tomato plants - Tousi N., Eini O., Ahmadvand R., Carra A., Miozzi L., Noris E., Accotto G.P. - Australasian Plant Pathology , 46: 379-386
  • 2016 - Multi-spot, label-free detection of viral infection in complexmediaby a non-reflectingsurface - Salina M., Giavazzi F., Ceccarello E., Damin F., Chiari M., Ciuffo M., Accotto G.P., Buscaglia M. - Sensors And Actuators. B, Chemical (Print), 957-962
  • 2016 - First report of Tomato leaf curl New Delhi virus affecting zucchini squash in an important horticultural area of southern Italy - Panno S., Iacono G., Davino M., Marchione S., Zappardo V., Bella P., Tomassoli L., Accotto G.P., Davino S. - New Disease Reports , pag. 6
  • 2014 - Transcriptomics of the interaction between the monopartite phloem-limited geminivirus tomato yellow leaf curl Sardinia virus and Solanum lycopersicum highlights a role for plant hormones, autophagy and plant immune system fine tuning during infection - Miozzi L., Napoli C., Sardo L., Accotto G.P. - Plos One , 9:e89951
  • 2014 - Multi-spot, Label-free Detection of Biomarkers in Complex Media by Reflectionless Surfaces - Salina M., Giavazzi F., Ceccarello E., Damin F., Chiari M., Ciuffo M., Accotto G.P., Buscaglia M. - Procedia Engineering , 87: 58-61
  • 2014 - The arbuscular mycorrhizal symbiosis attenuates symptom severity and reduces virus concentration in tomato infected by Tomato yellow leaf curl Sardinia virus (TYLCSV) - Maffei G., Miozzi L., Fiorilli V., Novero M., Lanfranco L., Accotto G.P. - Mycorrhiza, 24:179-186
  • 2013 - From immunity to susceptibility: Virus resistance induced in tomato by a silenced transgene is lost as TGS overcomes PTGS - Catoni, M., Lucioli, A., Doblas-Ibáñez, P., Accotto, G.P., Vaira, A.M. - Plant journal, 75:941-953
  • 2013 - Analysis of small RNAs derived from tomato yellow leaf curl Sardinia virus reveals a cross reaction between the major viral hotspot and the plant host genome - Miozzi L., Pantaleo V., Burgyán J., Accotto G.P., Noris E. - Virus Research, 178:287-296
  • 2012 - Recombination profiles between Tomato yellow leaf curl virus and Tomato yellow leaf curl Sardinia virus in laboratory and field conditions: evolutionary and taxonomic implications - Davino S., Miozzi L., Panno S., Rubio L., Davino M., Accotto G.P. - Journal of General Virology, 93:2712-2717
  • 2012 - The unconventional geminivirus Beet curly top Iran virus: satisfying Koch’s postulates and determining vector and host range - Soleimani R., Matic S., Taheri H., Behjatnia S.A.A., Vecchiati M., Izadpanah K., Accotto G.P. - Annals of Applied Biology, 162:174–181
  • 2011 - RNA viruses and their silencing suppressors boost Abutilon mosaic virus, but not the Old World Tomato yellow leaf curl Sardinia virus - Sardo L., Wege C., Kober S., Kocher C., Accotto G.P., Noris E. - Virus Research (06153J0), 161: 170-180
  • 2011 - Arbuscular mycorrhizal symbiosis limits foliar transcriptional responses to viral infection and favors long-term virus accumulationong-term Virus Accumulation - Miozzi L., Catoni M. Fiorilli V., Mullineaux P.M. , Accotto G.P., Lanfranco L. - Molecular Plant-microbe Interactions (09067J0), 24: 1562-1572
  • 2011 - An RGG sequence in the replication-associated protein (Rep) of Tomato yellow leaf curl Sardinia virus is involved in transcriptional repression and severely impacts resistance in Rep-expressing plants - Sardo L., Lucioli A., Tavazza M., Masenga V., Tavazza R., Accotto G.P., Noris E. - Journal Of General Virology (54890J0), 92: 204-209
  • 2010 - Transovarial Transmission Of Begomoviruses In Bemisia Tabaci - Accotto G.P., Sardo L. - In: Bemisia: Bionomics And Management Of A Global Pest, Editors: Philip A. Stansly, Steven E. Naranjo Publisher: Springer Science & Business Media B.V.
  • 2010 - ORTom: a multi-species approach based on conserved co-expression to identify putative functional relationships among genes in tomato - Miozzi L., Provero P., Accotto G.P. - Plant Molecular Biology, 73:519-532
  • 2010 - Introgression of resistance to two Mediterranean virus species causing tomato yellow leaf curl into a valuable traditional tomato variety - Barbieri M., Acciarri N., Sabatini E., Sardo L., Accotto G.P., Pecchioni N. - Journal Of Plant Pathology, 92:485-493
  • 2010 - The complete nucleotide sequence of an isolate of Tomato yellow leaf curl Sardinia virus found in Sicily - Davino S., Miozzi L., Accotto G.P. - Archives Of Virology, 155:1539-1542
  • 2009 - Comparative analysis of expression profiles in shoots and roots of tomato systemically infected by Tomato spotted wilt virus reveals organ-specific transcriptional responses - Catoni M., Miozzi L., Fiorilli V., Lanfranco L., Accotto G.P. - Molecular Plant-Microbe Interactions, 22:1504-1513
  • 2009 - Two new natural begomovirus recombinants associated with the tomato yellow leaf curl disease co-exist with parental viruses in tomato epidemics in Italy - Davino S., Napoli C., Dellacroce C., Miozzi L., Noris E., Davino M., Accotto G.P. - Virus Research, 143:15-23
  • 2009 - Global and cell-type gene expression profiles in tomato plants colonized by an arbuscular mycorrhizal fungus - Fiorilli V., Catoni M., Miozzi L., Novero M., Accotto G.P., Lanfranco L. - New Phytologist, 184:975-987
  • 2008 - Real-time PCR for the quantitation of tomato yellow leaf curl Sardinia virus in tomato plants and in Bemisia tabaci - Mason G., Caciagli P., Accotto G.p., Noris E., - Journal Of Virological Methods (03232J0), 147: 282-289
  • 2008 - A single-tube PCR assay for the detecting viruses and their recombinants that cause tomato yellow leaf curl disease in the mediterranean basin - Davino D., Davino M., Accotto G.P. - Journal Of Virological Methods (03232J0), 147: 93-98
  • 2008 - Ourmiavirus - Accotto G.P., Milne R.G. - Encyclopedia Of Virology, 5 Vols.. Oxford: Elsevier. P.500-501 (B.W.J. Mahy and M.H.V. Van Regenmortel, Editors), Publisher: Elsevier
  • 2008 - Potentiality of Methylation-sensitive Amplification Polymorphism (MSAP) in Identifying Genes Involved in Tomato Response to Tomato Yellow Leaf Curl Sardinia Virus - Mason G., Noris E., Lanteri S., Acquadro A., Accotto G.p., Portis E. - Plant Molecular Biology Reporter (11449J0), 26: 156-173
  • 2008 - Basil (Ocimum basilicum) a new host of Pepino mosaic virus - Davino, S., Accotto, G.p., Masenga, V., Torta, L., Davino, M. - New Disease Report , volume 18